Treatment may then be continued at the same dose given once a day. Saridomichelakis MN, Olivry T. An update on the treatment of canine atopic dermatitis. The results are problematic. All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. In atopic dermatitis, it is mainly mediated by a large group of proinflammatory and proallergic Th2 cytokines (e.g., interleukin [IL]-4, IL-5, IL-10, IL-13, IL-31). Apoquel is an anti-itch tablet given twice daily for the first . 405 HERON DRIVE SUITE 200 SWEDESBORO, NJ 08085-1749 | 2004-2023 WEDGEWOOD PHARMACY, ALL RIGHTS RESERVED. Breeding and Reproduction Horse breeding from planning through foal care; Diseases and Conditions Horse-health-problem risk factors, prevention, diagnosis, and treatment; Farm and Barn . Allergies can develop at any time, in any horse, and for virtually any reason. Gadeyne C, Little P, King VL, et al. While relatively safe for use in most horses, these potent anti-inflammatory drugs can cause a serious potential side effect in some individuals: an increased risk of developing the debilitating hoof disease laminitis. See how Apoquel works differently from steroids and cyclosporines, Discover how Apoquel can relieve allergic itch through an 8-week food trial, Hear from your peers about why Apoquel is their first choice for allergic itch relief, Explore the United States of Apoquel to see how Apoquel has benefited veterinarians in your region, Hear real stories of allergic itch relief from pet owners, See how Zoetis Petcare Rewards can benefit your practice, Informational resources for you to download and utilize within your practice, Provide additional information about Apoquel to pet owners with these resources, Continue therapy once daily (SID) thereafter for maintenance. Apoquel is typically administered in tablet form at 0.4-0.6mg per kilo of body weight, or 0.18-0.27mg per pound of body weight, every 12 hours or twice a day. A horse can hypothetically be allergic to anything he touches, inhales, ingests, or has applied to or injected into his body. This drug has been used in dogs with some pretty fabulous results. Apoquel. Apoquel Dosage. A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. My Docs are among the first in the country to use this drug on itchy and wheezy horses. While this is a very important strategy for some types of Equine Asthma ("classic" RAO), it may not be as important when managing those with Summer-Pasture-Associated disease. Immunotherapy, also called hyposensitization therapy, is a strategy used to gain allergen-specific immune tolerance, says Fultz. Nobody wants to be itchy and constantly scratching. In cats, this medication can cause excitement rather than sedation. Apoquel is an anti-allergy drug that's often prescribed by vets. Although oclacitinib is licensed for use in dogs, it has been reported to be effective to treat pruritus in allergic diseases in other species, including cats. I was one of the veterinarians involved in early field trials for Apoquel in horses. Several reports of successful use of oclacitinib to treat other diseases have been published.22-29 They include several cases of immune-mediated vascular diseases: idiopathic ear tip vasculitis in 4 dogs26 and ischemic dermatopathy in 6 dogs.28,29 In these reports, other classic medications had failed to control the disease until oclacitinib was added. This product is top-dressed onto the feed and helps horses with equine asthma, including heaves in older horses and inflammatory airway disease in young, athletic horses.". This encourages the natural drainage of irritants, allergens, and bacteria from the airways.. Haugh IM, Watson IT, Menter MA. 1. Most common side effects are vomiting and diarrhea. Acupuncture: It appears that some horses with Equine Asthma can benefit from acupuncture to help with breathing function. Read on below! Maximizing ventilation when horses are stalled and bedding with low-dust options such as wood byproducts; Purchasing dust- or mold-free hay and wetting, soaking, or steaming it prior to feeding to reduce inhaled particles; and Offering an alternative feed than hay for low-dust options. Dexamethasone: EZ Dose Micro Transdermal Gel, Dexamethasone: Twist-a-Dose Transdermal Gel, Discussion Guide for Pet Owners and Veterinarians, Medication Information for Pet and Horse Owners. On the topic of simple and economical allergy management, a readily accessible ingredient that helps many horses is, Recently, we have found that latex, which is everywhere in the horses environmentembedded in riding surfaces and racetracks, for examplemay be associated with severe equine asthma, he says. Option 4 is an oral tablet called Apoquel. Interestingly, the results suggest that oclacitinib has immunosuppressive properties, but only at a higher dosage than that approved on the label.30. 1,2 For over 30 years, Adequan i.m. Efficacy of oclacitinib (Apoquel) compared with prednisolone for the control of pruritus and clinical signs associated with allergic dermatitis in client-owned dogs in Australia. Schindler C, Levy DE, Decker T. JAK-STAT signaling: from interferons to cytokines. Since some horses have both "types" of asthma, you may need to try a stall without bedding, or experiment with different types of bedding. Apoquel is the #1 prescribed medicine for fast, effective relief of allergic itch and inflammation due to atopic and allergic dermatitis 1 Indications Control of pruritus associated with allergic dermatitis and control of atopic dermatitis in dogs at least 12 months of age. She is a New-York-based freelance author with a passion for equine health and veterinary care. This is totally random but figured Id mention it since I had no idea till I saw someone mention itZoetis has a rewards program and Apoquel is one of the drugs on it. We have been using an inflatable fleece e-collar on her . All product and company names are trademarks or registered trademarks of their respective holders. Many allergic reactions are evident as a mild case of transient hives. Pre-slaughter withdrawal time is 14 days following the last dose. 30. Horse dosing is 5 pills. Soaking hay can be time-consuming but is vital to helping horses that are showing signs of respiratory allergy., Feeding hay at ground level offers an added benefit: To maximize respiratory health, horses should spend portions of the day with their heads down, the way nature intended, she adds. Efficacy and safety of oclacitinib for the control of pruritus and associated skin lesions in dogs with canine allergic dermatitis. The frequency of urinary tract infection and subclinical bacteriuria in dogs with allergic dermatitis treated with oclacitinib: a prospective study. Do not use in breeding, pregnant, or lactating dogs. Its expensive, but its working. 16. 28. A blinded, randomized, placebo-controlled trial of the safety of oclacitinib in cats. Typically, a few sessions are required. Gadeyne et al compared prednisolone and oclacitinib at recommended doses and found that both drugs resulted in similar rapid effects with regard to pruritus and dermatitis reduction. It is absolutely miraculous for these itchy miserable horses. As a result, muscles relax and cause heavy sedation, notes DailyMed. Banovic F, Tarigo J, Gordon H, et al. This product came to the market in the US in Fall 2020. Option 2 is the Aservo Equihaler. For this first stretch, thats not going to get me too far since I need the loading dose up front. Its kind of cumbersome, but I have two on it, and they are doing better. 14. Not really cheap any way you shake it, but considering that she was on zyretc, dex, smarthbreathe ultra, respi-free previously. Webcast | Dosage Chart Oclacitinib should not be given in dogs younger than 12 months of age due to an increased risk for activating demodicosis, bacterial pneumonia, and other serious infections. If she suspects a product or ingredient to be the source of an allergic reaction, Fultz recommends performing elimination trials. 21. Is it possible to cure an allergy? Since it became available in 2014, several clinical studies have confirmed its antipruritic effect not only in dogs but also in cats, as well as in other immune-mediated diseases. Allergen avoidance and allergen-specific immunotherapy are measures that address the allergy itself; various drugs are available for symptomatic management. Cosgrove SB, Wren JA, Cleaver DM, et al. J Vet Pharmacol Ther 2014;37(4):317-324. A follow-up study assessed the long-term safety, efficacy, and quality of life of oclacitinib-treated dogs. Apoquel comes in tablet form only. So lets review why allergies happen, how they affect your horses body, and how to treat themor, better yet, how to avoid them altogether. Vet Dermatol 2019;30(2):87-90. 28. Dr. Nao Hensel obtained her doctor of veterinary medicine degree from Colorado State University in 2010. Feline idiopathic ulcerative dermatosis treated successfully with oclacitinib. Because insects are omnipresent in the horses environment at least some portion of the year, IBH is particularly labor-intensive to manage. Apoquel (oclacitinib tablet) Dosing & Administration How to dose Apoquel 0.4-0.6 mg/kg (0.18-0.27 mg/lb) Twice daily (BID) for up to 14 days Continue therapy once daily (SID) thereafter for maintenance May be given with or without food May discontinue without tapering Apoquel Dosing Guide Weight Range (lb) Number of Tablets to be Administered "Even though the drug is currently labeled for use in dogs (with. Its important to know, however, that some horses can have BOTH types, and will need to managed year-round!What are your treatment and management options? A blinded, randomized clinical trial comparing the efficacy and safety of oclacitinib and ciclosporin for the control of atopic dermatitis in client-owned dogs. Download Apoquel Information Sheet. Dosage and treatment schedule The recommended initial dose is 0.4 to 0.6 mg oclacitinib/kg bodyweight, administered orally, twice daily for up to 14 days. I have not tried to go less than that. But you're making a deal with the devil when you use these . Like most treatments, this medication will not be successful in every horse, but if it does work, it avoids the risks associated with steroids. Use of oclacitinib (Apoquel; Zoetis) for treatment of cutaneous mastocytosis in a cat. Lopes NL, Campos DR, Machado MA, et al. A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel) in client-owned dogs with atopic dermatitis. Speak to yourveterinarian in an emergency. Oclacitinib (APOQUEL) is a novel Janus kinase inhibitor with activity against cytokines involved in allergy. Ordering your pet's prescription drugs from Wedgewood Pharmacy is safe, and convenient. The downside is that it can cause laminitis and can suppress their immune system. Vet J 2016;207:29-37. Vet Dermatol 2015;26(1):23-30, e7-8. Pasture-associated equine asthma is most prevalent during the summer in the southeastern U.S. but has been reported worldwide. Some dogs exhibit increased pruritus when the dosage is reduced to once daily. Immunomodulatory in vitro effects of oclacitinib on canine T-cell proliferation and cytokine production. 4. J Biol Chem 2007;282(28):20059-20063. For atopic and allergic dermatitis, Apoquel may be given to dogs at a dosage of 0.18 - 0.27 mg/lb. Shes on 5 pills once a day for 7 days, after that we will drop to every other day, and then see how far we can space it out. Side effects have been rarely seen and documented, but the most common occurrences have been mild vomiting and diarrhea. Veterinarians are especially wary of administering corticosteroids to allergic horses that suffer from pituitary pars intermedia dysfunction, insulin dysregulation, and/or equine metabolic syndrome, because these conditions are also risk factors for laminitis.